С. А. Корниенко А. В. Кривопалов
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| Заключение
Появление геномных данных O. felineus существенно укрепляет базу молеку- лярно-биологических исследований эпидемиологически важных печеночных сосаль- щиков. Дальнейшее развитие этих работ должно учитывать острую потребность практического здравоохранения в эффективных средствах терапии и профилактики трематодозов. Работа выполнена при финансовой поддержке РФФИ (18-04-00417А) и Бюд- жетного проекта ИЦиГ СО РАН (0324-2019-0041). Литература 1. Shekhovtsov SV, Katokhin AV, Kolchanov NA, Mordvinov VA. The complete mitochondrial genomes of the liver flukes Opisthorchis felineus and Clonorchis sinensis (Trematoda). Parasitol Int. 2010; 59:100–103. 2. Ershov NI, Mordvinov VA, Prokhortchouk EB, Pakharukova MY, Gunbin KV, Ustyantsev K, et al. New insights from Opisthorchis felineus genome: update on genomics of the epidemiologically important liver flukes. BMC Genomics. 2019; 20: 399. 3. Ovchinnikov VY, Afonnikov DA, Vasiliev GV, Kashina EV, Sripa B, Mordvinov VA, Katokhin AV. Identification of microRNA genes in three opisthorchiids. PLoS Negl Trop Dis. 2015;9: e0003680. 4. Zadesenets KS, Katokhin AV, Mordvinov VA, Rubtsov NB. Comparative cytogenetics of opisthorchid species (Trematoda, Opisthorchiidae). Parasitol Int. 2012;61:87-9. 5. Pomaznoy MY, Logacheva MD, Young ND, Penin AA, Ershov NI, Katokhin AV, et al. Whole transcriptome profiling of adult and infective stages of the trematode Opisthorchis felineus. Parasitol Int. 2016;65:12–19. 6. Shekhovtsov SV, Katokhin AV, Romanov KV, Besprozvannykh VV, Fedorov KP, Yurlova NI, et al. A novel nuclear marker, pm-int9, for phylogenetic studies of Opisthorchis felineus, Opisthorchis viverrini, and Clonorchis sinensis (Opisthorchiidae, Trematoda). Parasitol Res. 2009;106: 293– 297. 7. Cai XQ, Liu GH, Song HQ, Wu CY, Zou FC, Yan HK, et al. Sequences and gene organization of the mitochondrial genomes of the liver flukes Opisthorchis viverrini and Clonorchis sinensis (Trematoda). Parasitol Res. 2012;110: 235–43. 8. Protasio AV, Tsai IJ, Babbage A, Nichol S, Hunt M, Aslett MA, et al. A systematically improved high quality genome and transcriptome of the human blood fluke Schistosoma mansoni. PLoS Negl Trop Dis. 2012;6:e1455. 9. L’vova MN, Duzhak TG, Tsentalovich IuP, Katokhin AV, Mordvinov VA. Secretome of the adult liver fluke Opisthorchis felineus. Parazitologiia. 2014 May-Jun;48(3): 169–184. 10. Callahan HL, Crouch RK, James ER. Helminth anti-oxidant enzymes: a protective mechanism against host oxidants? Parasitol Today. 1988;4: 218–225. 11. Donnelly S, O’Neill SM, Sekiya M, Mulcahy G, Dalton JP. Thioredoxin peroxidase secreted by Fasciola hepatica induces the alternative activation of macrophages. Infect Immun. 2005;73: 166–173. 12. Pakharukova MY, Kovner AV, Trigolubov AN, Fedin EN, Mikhailova ES, Shtofin SG, et al. Mechanisms of trematodiases pathogenicity: the presence of the secretory proteins from the liver fluke Opisthorchis felineus in the gallbladder tissues of the patients with chronic opisthorchiasis. Vavilov J. Genet. Breed. 2017;21, 312–316. Материалы VI межрегиональной научной конференции, 4–6 сентября 2019 103 13. Gouveia MJ, Pakharukova MY, Laha T, Sripa B, Maksimova GA, Rinaldi G, et al. Infection with Opisthorchis felineus induces intraepithelial neoplasia of the biliary tract in a rodent model. Carcinogenesis. 2017;38: 929–937. 14. Mordvinov VA, Shilov AG, Pakharukova MY. Anthelmintic activity of cytochrome P450 inhibitors miconazole and clotrimazole: in-vitro effect on the liver fluke Opisthorchis felineus. Int J Antimicrob Agents. 2017;50: 97–100. жүктеу/скачать 7.14 Mb. Достарыңызбен бөлісу:
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