Эпигаллокатехин и рак
Epigallocatechin-3-Gallate (EGCG)
жүктеу/скачать 1.88 Mb.
|
- Бұл бет үшін навигация:
- 5.1. miRNAs Targeting Oncogenes
- 5.2. miRNAs Targeting Tumour Suppressor Genes
- 5.3. Other miRNAs
- Green tea compounds in breast cancer prevention and treatment.
- Abstract
5. Epigallocatechin-3-Gallate (EGCG)The epigallocatechin-3-gallate (EGCG) is the major polyphenol found in green tea (Camellia sinensis) with anticancer effects. Previous reports have shown that it is able to suppress proliferation, induce apoptosis, and inhibit invasion, angiogenesis, and metastasis in various cancer types in both in vitro and in vivo models by targeting multiple cellular signalling pathways [102, 103]. 5.1. miRNAs Targeting OncogenesTreatment with EGCG in HepG2 hepatocellular carcinoma cells altered the expression of 61 miRNAs (13 upregulated and 48 downregulated) and among the upregulated miRNAs is miR-16. Its target, Bcl-2, was also downregulated by EGCG. Suppression of miR-16 counteracted the effects of EGCG on apoptosis induction and Bcl-2 downregulation [57]. 5.2. miRNAs Targeting Tumour Suppressor GenesBesides that, it was also reported that EGCG enhanced the effects of cisplatin by downregulating miR-98-5p in A549 lung cancer cells. Inhibition of miR-98-5p enhanced cisplatin-induced cell death and increased expression of p53 [74]. 5.3. Other miRNAsIn HepG2 hepatocellular carcinoma cells, five miRNAs (miR-30b  , miR-453, miR-520-e, miR-629, and miR-608) were downregulated following treatment with EGCG. Bioinformatics analysis revealed gene targets of miR-30b to be involved in regulating various pathways including inflammation, NF-κB, peroxisome proliferator-activated receptor (PPAR) signalling, insulin signalling, glycolysis and gluconeogenesis, glycerolipid metabolism, mitochondria and oxidative phosphorylation, and glutathione metabolism [104]. EGCG upregulated miR-210, a key component of hypoxia-inducible factor 1α (HIF-1α), through the hypoxia-response element found in the promoter region, in both H1299 and H460 non-small-cell lung cancer and CL13 mouse lung adenocarcinoma cell lines. Overexpression of miR-210 reduced cell proliferation rate and anchorage-independent growth [105]. In a study by Chakrabarti et al., it was reported that EGCG downregulated three oncogenic miRNAs (miR-92, miR-93, and miR-106b) and upregulated three tumour suppressive miRNAs (miR-7-1, miR-34a, andmiR-99a), leading to induction of both intrinsic and extrinsic apoptotic pathways in SK-N-BE2 and IMR-32 malignant neuroblastoma cell lines. The alterations in expression of these miRNAs were found to be more significant when treated with EGCG in combination with N-(4-hydroxyphenyl) retinamide (4-HPR), and overexpression of miR-93 and miR-7-1, which exhibited the highest fold-change, decreased and increased efficacy towards EGCG, respectively [106]. The 4-HPR is a synthetic retinoid that has been reported by Reynolds et al., to induce differentiation of neuroblastoma cells and increase survival rates in neuroblastoma patients [107]. Overexpression of miR-93 and miR-7-1, which exhibited the highest fold-change, decreased and increased efficacy towards EGCG, respectively [107]. Similar results were reported on SH-SY5Y and SK-N-DZ malignant neuroblastoma cell lines when used as stand-alone agent [108]. Meanwhile, it was found that oncogenic miR-21 was downregulated while tumour suppressive miR-330 was upregulated in prostate cancer xenograft tissues of EGCG-treated mice [109].
Зеленый чай соединений в рак молочной железы профилактика и лечение. Рак молочной железы является наиболее распространенным раком среди женщин. В последние годы многие исследования in vitro и in vivo исследования показывают, что зеленый чай обладает анти-рак эффекты. В эпидемиологических исследованиях, однако, дали неоднозначные результаты у людей. Аналогично, результаты на животных моделях, об профилактические или терапевтические эффекты зеленого чая компоненты являются неубедительными. Механизмы, с помощью которых потребление зеленого чая может влиять на риск рака молочной железы у человека, остаются неясными механизмы, с помощью которых потребление зеленого чая может влиять. Здесь мы обзор недавние исследования зеленого чая полифенолы и их применение в профилактике и лечении рака молочной железы. Кроме того, мы рассмотрим влияние зеленого чая компоненты молочной железы путем анализа эпидемиологических исследований, в исследованиях на животных моделях и в клинических испытаниях. Наконец, мы обсудим механизмы, с помощью которых компоненты зеленого чая подавляют развитие и рецидив рака молочной железы. Лучшее понимание механизмов улучшения использования зеленого чая при раке молочной железы профилактика и терапия и готовят почву для новых стратегий по профилактике и лечению молочной железы. World J Clin Oncol. 2014 Aug 10;5(3):520-8. doi: 10.5306/wjco.v5.i3.520. Green tea compounds in breast cancer prevention and treatment.Li MJ1, Yin YC1, Wang J1, Jiang YF1. Author information
AbstractBreast cancer is the most common cancer among women. In recent years, many in vitro and in vivo studies indicate that green tea possesses anti-cancer effects. The epidemiological studies, however, have produced inconclusive results in humans. Likewise, results from animal models about the preventive or therapeutic effects of green tea components are inconclusive. The mechanisms by which green tea intake may influence the risk of breast cancer in humans remain elusive mechanisms by which green tea intake may influence. Here, we review recent studies of green tea polyphenols and their applications in the prevention and treatment of breast cancer. Furthermore, we discuss the effect of green tea components on breast cancer by reviewing epidemiological studies, animal model studies and clinical trials. At last, we discuss the mechanisms by which green tea components suppress the development and recurrence of breast cancer. A better understanding of the mechanisms will improve the utilization of green tea in breast cancer prevention and therapy and pave the way to novel prevention and treatment strategies for breast cancer. жүктеу/скачать 1.88 Mb. Достарыңызбен бөлісу:
|