лабораторных условиях при изучении высвобождения фексофенадина.
Ключевые слова: фексофенадин, высвобождение, гели, спектрофотомерия, валидация.
THE STUDY OF THE BIOAVAILABILITY GELS OF FEXOFENADINE IN
EXPERIMENTS IN VITRO
Khadzhieva Z.D.
1
, Chumakova V.A.
2
, Gubanova L.B.
1
1
Pyatigorsk medical-pharmaceutical Institute, 357532, Stavropol territory, Pyatigorsk-32, prospect Kalinina 11
,
zara-
farm@mail.ru
2
Budgetary institution of the Voronezh region «The Voronezh center of quality control and certification of medicines",
394051, Voronezh, St. Writer Marshak D. 1
,
v.chumakova@yandex.ru
Studied the release of Fexofenadine model samples from five gels, the method of equilibrium dialysis using a
semipermeable membrane in vitro. An important indicator of the quality of the gels is the ability to provide
bioavailability of the drug substance. By varying different combinations of excipients that can adjust the
strength and duration of therapeutic action of the gel, to regulate the bioavailability of active ingredients. As
carriers to develop a soft dosage forms Fexofenadine gel studied the basics, widely used in production.
Comparative evaluation of the degree of drug release from data bases showed that the optimum for further
study are the basis of HPMC with glycerol (sample 2) and an alloy of polyethylene oxides with molecular weights
of 1500 to 400 in the ratio of 1:5 (sample 3). Developed spectrophotometric method for the quantitative
determination of Fexofenadinein dialysis. Metrological evaluation of the methodology carried out according to
the criteria of accuracy, reproducibility and linearity, and it is shown that it can be used in the laboratory when
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