С. А. Корниенко А. В. Кривопалов
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- OXIDATIVE HEPATOBILIARY LESIONS DURING EXPERIMENTAL OPISTHORCHIASIS ACCUMULATES ON TIME-DEPENDENT MANNER OF INFECTION
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Беэр С.А. 2005. Биология возбудителя описторхоза. М.: КМК. 336 с. Gouveia M.J., Pakharukova M.Y., Laha T., Sripa B., Maksimova G.A., Rinaldi G., Brindley P.J., Mordvinov V.A., Amaro T., Santos L.L., Correia da Costa J.M., Vale N. 2017. Infection with Opisthorchis felineus induces intraepithelial neoplasia of the biliary tract in a rodent model // Carcinogenesis. Vol. 38. No. 9. P. 929–937. doi:10.1093/carcin/bgx042. Maksimova G.A., Pakharukova M.Y., Kashina E.V., Zhukova N.A., Kovner A.V., Lvova M.N., Katokhin A.V., Tolstikova T.G., Sripa B., Mordvinov V.A. 2017. Effect of Opisthorchis felineus infection and dimethylnitrosamine administration on the induction of cholangiocarcinoma in Syrian hamsters // Parasitol Int. Vol. 66. P. 458–463. doi:10.1016/j.parint.2015.10.002. Pakharukova M.Y., Zaparina O.G., Kapushchak Y.K., Baginskaya N.V., Mordvinov V.A. 2019. Opisthorchis felineus infection provokes timedependent accumulation of oxidative hepatobiliary lesions in the injured hamster liver. PLoS ONE 14(5): e0216757. Pakharukova M.Y., Correia da Costa J.M., Mordvinov V.A. 2019. The liver fluke Opisthorchis felineus as a group III or group I // Carcinogenesis. 4open 2019, 2, 23. Sripa B., Kaewkes S., Sithithaworn P., Mairiang E., Laha T., Smout M., Loukas A. 2007. Liver fluke induces cholangiocarcinoma // PLoS Med. 4. e201. OXIDATIVE HEPATOBILIARY LESIONS DURING EXPERIMENTAL OPISTHORCHIASIS ACCUMULATES ON TIME-DEPENDENT MANNER OF INFECTION Zaparina O.G., Kovner A.V., Mordvinov V.A., Pakharukova M.Y. Opisthorchiasis caused by the liver fluke Opisthorchis felineus is widespread on Russian territory. The largest area affected by opisthorchiasis felinea occupies almost the entire territory of Western Siberia. This disease is accompanied by liver disorders including periductal fibrosis, cholangiofibrosis, biliary neoplasia with the potential of cholangiocarcinoma. The causative agents of these diseases, liver flukes O. viverrini and C. sinensis, are officially recognized as Group 1 biological carcinogens and are classified as the main risk factors for cholangiocarcinoma. Recently specific oxysterol-like molecules were found to be secreted from the flukes. These molecules might have genotoxic and pro-oxidative properties, increase production of reactive oxygen species, oxidative damage to DNA and precancerous lesions in host cells. To study the possible role of oxidative stress in the pathogenesis of opisthorchiasis we assessed lipid peroxidation marker accumulation, DNA damage in infected hamsters from 1 to 18 months postinfection and the effect of mitochondrial antioxidant SKQ1 (10- (6'-Plastoquinonyl) decyltriphenylphosphonium)). We showed time-dependent accumulation of inflammatory, lipid peroxidation (MDA, HNE) and oxidative DNA damage (8- OHdG) markers. Moreover, liver histopathology, including inflammation, dysplasia, periductal Материалы VI межрегиональной научной конференции, 4–6 сентября 2019 59 fibrosis were assessed using morphometry analysis. The histopathology of liver i.e. biliary neoplasia, lipid peroxidation markers and serum biochemistry liver damage markers were significantly attenuated by SKQ1 treatment. Thus, reactive oxygen species play a pivotal role in the pathogenesis of opisthorchiasis, probably mediating the processes of inflammation and dysplasia of the bile ducts. SKQ1 has a hepatoprotective effect on the liver by reducing oxidative stress. жүктеу/скачать 7.14 Mb. Достарыңызбен бөлісу:
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