Обзоры по клинической фармакологии и лекарственной терапии том 2016/14/3 о влИянии наночАСтИц оксидов метАллов на фИзИОлогию жИВых организмОВ
ABout thE infLuEnCE of mEtAL oxidE nAnoPArtiCLEs
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| ABout thE infLuEnCE of mEtAL oxidE nAnoPArtiCLEs
on Living orgAnisms PhysioLogy © О.А. Zeinalov 1 , S.P. Kombarova 1 , D.V. Bagrov 2 , M.A. Petrosyan 3 , G.H. Tolibova 3 , A.V. Feofanov 2 , K.V. Shaitan 2 1 LLC “PharmGene Technology”, Moscow, Russia; 2 M.V. Lomonosov Moscow State University, Faculty of Biology, Moscow, Russia; 3 D.O. Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, Saint Petersburg, Russia For citation: Reviews on Clinical Pharmacology and Drug Therapy, 2016;14(3):24-33 Received: 01.07.2016 Accepted: 16.08.2016 Keyword: nanotechnology; metal oxides nanopartic- les; characterization of nanoparticles; transmission electron microscopy; biosystems; biosafety; primary monitoring; laboratory mice; physiology; intoxication; indicators of animal behavior; hematological and biochemical parameters of blood. AAdsoras. Recently the number of materials and goods produced by nanotechnology has been growing rapidly, leading to an increased penetration of nanoparticles into biosystems. To assess the risks associated with the production and circulation of nanoproducts should be developed methods for the rapid diagnostics of nanopathology. In this work, it has been experimentally shown that the introduction of metal oxides nanoparticles (TiO 2 , ZnO, Al 2 O 3 , CeO 2 ) to laboratory mice leads to changes some profiles of specific hematological and biochemical blood parameters. Therefore for the purpose of early detection of symptoms of intoxication as benchmarks of the influence of metal oxide nanoparticles on living organisms can recommend express monitoring of peripheral blood (red blood parameters) and biochemical parameters of blood serum (activity of aminotransferases and indicators of nitrogen metabolism). The chosen indicators of blood can serve as diagnostic biomarkers in the development of rapid tests of primary monitoring of the impact of metal oxide nanoparticles on biological systems. ТОМ 2016/14/3 ОБЗОРЫ ПО КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИ И ЛЕКАРСТВЕННОЙ ТЕРАПИИ 25 оригинальные исследования жүктеу/скачать 0.86 Mb. Достарыңызбен бөлісу:
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