34. Draw up a technological scheme for the production of tooth elixir. Define parameters for quality assessment.
Technology of dental elixirs
1. Preparation of raw materials
2. Preparation of dental elixir, including the following operations:
- introduction of biologically active additives and excipients into the solvent;
- settling;
- filtration.
3. Filling into bottles, packaging, labeling of the finished product.
Quality control of dental elixirs
Dental elixirs are manufactured in accordance with the requirements of regulatory
documentation, according to technological instructions and recipesapproved in the
prescribed manner.
quality indicators of tooth elixir:
Appearance: homogeneous transparent liquid
Color - characteristic
The smell is pleasant, characteristic
Taste is pleasant
35. Suggest the composition and recipe for preparing powderedpowder and describe the main technological operations. Determinequality assessment parameters.
Stages of powder extraction technology. 1) powder preparation technology consists of the following steps: * grinding;* Sieve;* mixing;* dosage (measurement);* packaging and decoration;* quality assessment
Grinders can be classified according to different criteria:
* - by purpose: preliminary and final grinding;
* - depending on the method of grinding the material,
* - depending on the degree of grinding of the material (large, medium and small shredders 2) sieving-when complex powders are obtained in industrial conditions, each substance included in the mixture is ground separately and sievedaccordingly . 3) mixing-all components are poured into a mixer and mixed until a homogeneous mixture is obtained. When mixing, it is necessary to takeinto account the nature of the powdery material . The main principle of mixing is that a small amount of substances is added to a large amount soas not to lose a small amount.
4) packaging and packaging of powders.
5) standardization of powders is carried out by testing in accordancewith the methods listed in the HFU: * - description;-* identification* - crushing
* uniformity of the mass of the active substance or the composition of powders in containers for single doses
* loss of mass or presence of water during drying;
* - accompanying additives;
* - quantitative content of active substances and antimicrobialpreservatives
* Quality assessment parameters
* 1) compatibility of medicines in the prescription document
* 2) correct choice of packaging-dosage powders in jars or bottles, whendosing in gelatin capsules
* 3) the correct indication of the prescription number, pharmacy numberand address, patient name; "internal" or "external" plate with the inscription "powders", method of application, date of manufacture (day, month, year), expiration date; price of the drug. Notes on dosage forms 4) organoleptic control. It is carried out by checking the compliance of the powder with the ingredients included in the color, taste, smell. 5) visual control of the uniformity of powders during production: individual particles visible when pressing the powder mixture with a pestlecannot be detected.
* 6) liquidity. When pouring powders into capsules, the mass of the powder should be dry, loose, without lumps or sticking to the capsule.
* 7) differences in the mass of individual powders
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