| ПРИЛОЖЕНИЕ А
Таблица А.1 - Гены с наличием мутаций, при раке толстой кишки
Хромо-сома
|
Ген
|
Синонимические названия генов
|
Хромо-сома
|
Ген
|
Синонимические названия генов
|
1
|
RAD54L
|
HR54; hHR54; RAD54A; hRAD54; RAD54L
|
2
|
LRP2
|
DBS; gp330; LRP2
|
1
|
MUTYH
|
MYH; CYP2C; MGC4416; MUTYH
|
2
|
MAP2
|
MAP2A; MAP2B; MAP2C; DKFZp686I2148; MAP2
|
1
|
MTHFR
|
CLC-6; KIAA0046
|
3
|
CNTN4
|
AXCAM; BIG-2; CNTN4A; MGC33615
|
1
|
LGR6
|
GPCR; FLJ14471; VTS20631; LGR6
|
3
|
EPHA3
|
ETK; HEK; ETK1; HEK4; TYRO4; EPHA3
|
1
|
MCP
|
MCP; TLX; AHUS2; MIC10; TRA2.10; MGC26544; CD46
|
3
|
TNFSF10
|
TL2; APO2L; CD253; TRAIL; Apo-2L; TNFSF10
|
1
|
OBSCN
|
UNC89; FLJ14124; KIAA1556; KIAA1639; DKFZp666E245; OBSCN
|
3
|
GSK3B
|
|
1
|
PTPRU
|
FMI; PTP; PCP-2; PTP-J; PTPRO; PTPU2; GLEPP1; PTP-PI; PTPPSI; hPTP-J; FLJ37530; R-PTP-PSI; PTPRU
|
3
|
TGFBR2
|
AAT3; FAA3; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII; TGFBR2
|
1
|
OMA1
|
DAB1; MPRP-1; YKR087C; ZMPOMA1; FLJ33782; 2010001O09Rik; OMA1
|
3
|
MLH1
|
FCC2; COCA2; HNPCC; hMLH1; HNPCC2; MGC5172; MLH1
|
2
|
EPCAM
|
DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK-1, TACSTD1, TROP1
|
3
|
PIK3CA
|
PI3K; MGC142161; MGC142163; p110-alpha; PIK3CA
|
2
|
BUB1
|
BUB1A; BUB1L; hBUB1; BUB1
|
3
|
CTNNB1
|
OK/SW-cl.35, CTNNB
|
2
|
FZD7
|
FzE3
|
3
|
ALCAM
|
MEMD; CD166
|
2
|
MSH2
|
COCA1, FCC1, HNPCC, HNPCC1, LCFS2
|
3
|
PPAR-γ
|
GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARgamma; PPARG
|
2
|
ODC1
|
ODC; ODC1
|
3
|
CHL1
|
CALL; L1CAM2; FLJ44930; MGC132578; CHL1
|
2
|
MSH6
|
GTBP; HSAP; HNPCC5; MSH6
|
3
|
P2RY14
|
P2Y14; GPR105; KIAA0001; P2RY14
|
2
|
PMS1
|
PMSL1; hPMS1; HNPCC3; FLJ98259; DKFZp781M0253; PMS1
|
3
|
TTLL3
|
HOTTL; FLJ13898; DKFZp434B103; DKFZp686D076; TTLL3
|
Продолжение таблицы А.1
Хромо-сома
|
Ген
|
Синонимические названия генов
|
Хромо-сома
|
Ген
|
Синонимические названия генов
|
4
|
ABCG2
|
MRX; MXR; ABCP; BCRP; BMDP; MXR1; ABC15; BCRP1; CD338; GOUT1; CDw338; UAQTL1
|
6
|
PKHD1
|
FCYT; ARPKD; TIGM1; FLJ46150; DKFZp686C01112; PKHD1
|
4
|
FGFR3
|
ACH; CEK2; JTK4; CD333; HSFGFR3EX; FGFR3
|
6
|
KCNQ5
|
Kv7.5; KCNQ5
|
4
|
KIT
|
PBT; SCFR; C-Kit; CD117; KIT
|
6
|
C6orf29
|
CTL4; NG22; C6orf29; FLJ14491; SLC44A4
|
4
|
ADAM29
|
CT73; svph1; ADAM29
|
6
|
SLC29A1
|
ENT1; MGC1465; MGC3778; SLC29A1
|
4
|
FBXW7
|
AGO; CDC4; FBW6; FBW7; FBX30; FBXW6; SEL10; FBXO30; SEL-10; FLJ16457; DKFZp686F23254; FBXW7
|
6
|
SYNE1
|
8B; CPG2; EDMD4; MYNE1; SCAR8; C6orf98; FLJ30878; FLJ41140; dJ45H2.2; DKFZp781J13156; SYNE1
|
4
|
PROM1
|
MSTP061, AC133, CD133, CORD12, MCDR2, PROML1, RP41, STGD4
|
7
|
BRAF
|
BRAF1, RAFB1, B-raf 1, MGC126806
|
5
|
MSH3
|
DUP, MRP1
|
7
|
PTPN12
|
PTP-PEST; PTPG1
|
5
|
APC
|
GS; DP2; DP3; BTPS2; DP2.5; APC
|
7
|
PMS2
|
PMSL2; HNPCC4; PMS2CL; PMS2
|
6
|
HIST1H1B
|
H1; H1.5; H1F5; MGC126630; MGC126632; HIST1H1B
|
7
|
MET
|
AUTS9; c-Met; HGFR; RCCP2
|
6
|
EYA4
|
CMD1J; DFNA10; EYA4
|
7
|
EPHB6
|
HEP; MGC129910; MGC129911; EPHB6
|
6
|
VEGFA
|
VPF; VEGF; MVCD1
|
7
|
MLL3
|
HALR; KMT2C; FLJ12625; FLJ38309; DKFZp686C08112; MLL3
|
6
|
CD109
|
CPAMD7; FLJ38569; FLJ41966; RP11-525G3.1; DKFZp762L1111; CD109
|
7
|
SEC8L1
(EXOC4)
|
REC8; SEC8; Sec8p; SEC8L1; MGC27170; EXOC4
|
6
|
HFE
|
dJ221C16.10.1; HFE1; HH; HLA-H; MGC103790
|
7
|
EGFR
|
ERBB; HER1; mENA; ERBB1; PIG61; EGFR
|
6
|
PHIP
|
ndrp; WDR11; DCAF14; FLJ20705; FLJ45918; MGC90216; PHIP
|
7
|
ABCB1
|
CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170
|
Продолжение таблицы А.1
Хромо-сома
|
Ген
|
Синонимические названия генов
|
Хромо-сома
|
Ген
|
Синонимические названия генов
|
8
|
RUNX1T1
|
CDR; ETO; MTG8; MTG8b; AML1T1; ZMYND2; CBFA2T1; MGC2796; RUNX1T1
|
10
|
RET
|
PTC; MTC1; HSCR1; MEN2A; MEN2B; RET51; CDHF12; RET-ELE1; RET
|
8
|
PDGFRL
|
PDGRL
|
10
|
TCF7L2
|
TCF4; TCF-4; TCF7L2
|
8
|
MYC
|
bHLHe39; c-Myc; MRTL
|
10
|
ADAMTS15
|
MGC126403; ADAMTS15
|
8
|
LOC157697
|
HSPC319; ERICH1; LOC157697
|
10
|
ZEB1
|
RP11-472N13.4, AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A
|
8
|
CSMD3
|
KIAA1894; CSMD3
|
11
|
BAD
|
BBC2; BCL2L8; BAD
|
8
|
DLC1
|
HRA
|
11
|
MMP1
|
CLG; CLGN
|
9
|
ENG
|
RP11-228B15.2, CD105, END, HHT1, ORW, ORW1
|
11
|
PTEN
|
BZS; MHAM; TEP1; MMAC1; PTEN1; 10q23del; MGC11227; PTEN
|
9
|
TGFBR1
|
AAT5; ALK5; SKR4; ALK-5; LDS1A; LDS2A; TGFR-1; ACVRLK4; TGFBR1
|
11
|
PTPRJ
|
DEP1; SCC1; CD148; HPTPeta; R-PTP-ETA; PTPRJ
|
9
|
ABC1
|
ABC-1; ABC1; CERP; FLJ14958; HDLDT1;MGC164864; MGC165011; TGD
|
11
|
HRAS
|
C-BAS/HAS; C-H-RAS; C-HA-RAS1; CTLO
|
9
|
UHRF2
|
NIRF; URF2; RNF107; MGC33463; DKFZp434B0920; DKFZp686G0837; RP11-472F14.2; UHRF2
|
11
|
CD44
|
AL133330.1, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1
|
9
|
PTPRD
|
HPTP; PTPD; HPTPD; HPTPDELTA; RPTPDELTA; PTPRD
|
11
|
CD248
|
TEM1; CD164L1; MGC119478; MGC119479; CD248
|
9
|
DBC1
|
FAM5A; DBCCR1; DBC1
|
11
|
CCND1
|
BCL1; D11S287E; PRAD1; U21B31
|
10
|
C10orf137
|
EDRF1; MGC125705; RP11-383C5.6; C10orf137
|
11
|
GUCY1A2
|
GC-SA2; GUC1A2; GUCY1A2
|
10
|
ABCC2
|
DJS; MRP2; cMRP; ABC30; CMOAT
|
11
|
SCN3B
|
SCNB3; HSA243396; SCN3B
|
10
|
ACSL5
|
ACS2; ACS5; FACL5; ACSL5
|
12
|
KRAS
|
NS; NS3; KRAS1; KRAS2; RASK2; KI-RAS; C-K-RAS; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KRAS
|
10
|
ERCC6
|
CSB; CKN2; COFS; ARMD5; COFS1; RAD26; ERCC6
|
12
|
K6IRS3
|
K6IRS3; IRT6IRS3; KRT6IRS3; MGC129635; MGC129636; KRT73
|
Продолжение таблицы А.1
Хромо-сома
|
Ген
|
Синонимические названия генов
|
Хромо-сома
|
Ген
|
Синонимические названия генов
|
|
12
|
P2RX7
|
P2X7; MGC20089; P2RX7
|
15
|
C15orf2
|
C15orf2
|
|
12
|
VDR
|
NR1I1
|
15
|
MKRN3
|
D15S9; RNF63; ZFP127; ZNF127; MGC88288; MKRN3
|
|
13
|
KLF12
|
AP2REP; AP-2rep; HSPC122
|
16
|
ADAMTS18
|
ADAMTS21; ADAMTS18
|
|
13
|
CDK8
|
K35; MGC126074; MGC126075; CDK8
|
16
|
CDH1
|
UVO; CDHE; ECAD; LCAM; Arc-1; CD324; CDH1
|
|
13
|
IRS2
|
IRS2
|
16
|
AXIN1
|
AXIN; PPP1R49
|
|
13
|
LMO7
|
LOMP; FBX20; FBXO20; KIAA0858; LMO7
|
16
|
GALNS
|
GAS; MPS4A; FLJ17434; FLJ42844; FLJ98217; GALNAC6S; GALNS
|
|
14
|
MLH3
|
HNPCC; HNPCC7; S240II117
|
16
|
MMP2
|
CLG4; MONA; CLG4A; TBE-1; MMP-II; MMP2
|
|
14
|
EVL
|
RNB6; EVL
|
16
|
UQCRC2
|
QCR2; UQCR2; UQCRC2
|
|
14
|
AKT
|
AKT; PKB; RAC; PRKBA; MGC99656; PKB-ALPHA; RAC-ALPHA; AKT1
|
16
|
ZNF442
|
FLJ14356; ZNF442
|
|
14
|
PRKD1
|
PKD; PKCM; PRKCM; PKC-MU; PRKD1
|
17
|
AXIN2
|
AXIL; MGC10366; MGC126582; DKFZp781B0869; AXIN2
|
|
14
|
KIAA1409
|
FLJ43337
|
17
|
FLCN
|
BHD; FLCL; FLJ45004; FLJ99377; MGC17998; MGC23445; DKFZp547A118; FLCN
|
15
|
NEUGRIN
|
DSC92; NGRN
|
17
|
TP53
|
p53; LFS1; TRP53; FLJ92943; TP53
|
|
15
|
SMAD3
|
MADH3; JV15-2; HSPC193; HsT17436; MGC60396; DKFZp586N0721; DKFZp686J10186; SMAD3
|
17
|
EPPB9
|
B9; EPPB9; MKSR1; B9D1
|
|
15
|
MAPK6
|
ERK3; PRKM6; p97MAPK; HsT17250; DKFZp686F03189; MAPK6
|
17
|
MAP2K4
|
NKK; MEK4; MKK4; SEK1; JNKK1; SERK1; MAPKK4; PRKMK4; MAP2K4
|
|
15
|
ADAMTSL3
|
KIAA1233; MGC150716; MGC150717; ADAMTSL3
|
17
|
NF1
|
WSS; NFNS; VRNF; FLJ21220; DKFZp686J1293; NF1
|
|
15
|
BLM
|
BS; MGC126616; MGC131618; MGC131620; RECQ2
|
18
|
DCC
|
CRC18; CRCR1; IGDCC1; DCC
|
|
Продолжение таблицы А.1
Хромо-сома
|
Ген
|
Синонимические названия генов
|
Хромо-сома
|
Ген
|
Синонимические названия генов
|
18
|
SMAD2
|
hMAD-2; hSMAD2; JV18; JV18-1; MADH2; MADR2
|
20
|
MMP9
|
GELB; CLG4B; MMP-9; MANDP2; MMP9
|
18
|
SMAD4
|
JIP; DPC4; MADH4; SMAD4
|
20
|
SRC
|
ASV; SRC1; c-SRC; p60-Src; SRC
|
18
|
ATP5A1
|
OMR; ORM; ATPM; MOM2; ATP5A; hATP1; ATP5AL2; ATP5A1
|
20
|
PLCG1
|
PLC1; NCKAP3; PLC-II; PLC148; PLCgamma1; PLCG1
|
18
|
ZNF521
|
EHZF; Evi3; DKFZp564D0764; ZNF521
|
20
|
SNAI1
|
SLUGH2, SNA, SNAH, SNAIL, SNAIL1, dJ710H13.1
|
19
|
BAX
|
BCL2L4
|
20
|
SFRS6
|
B52; SRP55; MGC5045; FLJ08061; SFRS6
|
19
|
ZNF480
|
MGC32104; ZNF480
|
21
|
PKNOX1
|
PREP1; pkonx1c; PKNOX1
|
19
|
ZNF155
|
pHZ-96; MGC161655; ZNF155
|
22
|
CHEK2
|
CDS1; CHK2; LFS2; RAD53; HuCds1; PP1425; CHEK2
|
19
|
MGC33407
|
HSD21; MGC33407; ACTL9
|
22
|
EP300
|
p300; KAT3B; EP300
|
20
|
SDBCAG84
|
Erv46; CGI-54; PRO0989; C20orf47; NY-BR-84; SDBCAG84; dJ477O4.2; ERGIC3
|
22
|
GSTT1
|
no
|
20
|
GNAS
|
AHO; GSA; GSP; POH; GPSA; NESP; GNAS1; C20orf45; MGC33735; GNAS
|
x
|
TBX22
|
CLPA; TBXX; dJ795G23.1; TBX22
|
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